Critical Appraisal

Null hypothesis significance testing: a short tutorial

In this short tutorial, I first summarize the concepts behind the method, distinguishing test of significance (Fisher) and test of acceptance (Newman-Pearson) and point to common interpretation errors regarding the p-value. I then present the related concepts of confidence intervals and again point to common […]

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Classifying the evidence from clinical trials – the need to consider other dimensions

The current approach to assessing the quality of evidenceobtained from clinical trials focuses on three dimensions: thequality of the design (with double-blinded randomised controlledtrials representing the highest level of such design); the statisticalpower (beta) and the level of significance (alpha). While theseaspects are important, we

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