Evidence based medicine, using randomized controlled trials and metaanalyses as the major tools and sources ofevidence about average results for heterogeneous groups of patients, developed as a reaction against poorly designed observational treatment research and physician reliance on personal experience with other patients as a guideto decision-making about a patient at hand. However, these tools do not answer the clinician’s question: “Will agiven therapeutic regimen help my patient at a given point in her/his clinical course?” We introduce fine-grainedprofiling of the patient at hand, accompanied by comparative evidence of responses from approximate matches tothis patient on whom a contemplated treatment has/has not been administered. This represents medicine based ev-idence that is tuned to decision-making for the particular patient.

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Resource quality according to evaluation criteria, range 0-32: 28